GEORGIA
W. MADDUX, FLOYD M. FOLTZ AND
STANLEY R. NELSON
ABSTRACT
Increased
intracranial pressure occurs in both acute and chronic hypervitaminosis A in
man, but a decreased cerebrospinal fluid (CSF) pressure has beenreported in
various laboratory animals treated chronically with vitamin A. In order to clarify
this difference in findings, measurements of brain water and CSF pressure were made
in immature and mature rats treated with high doses of vitamin A. No pressure or
brain water changes were observed in the acutely treated mature rats, but those
treated chronically for 6 to 8 days had a 93% decrease in CSF pressure. Brain
edema was also present in the treated animals; brain volume increased 2.0% in
immature rats and 4.8% in mature rats. When the CSF pressure of chronically
treated mature rats was raised to a normal CSF pressure by the addition of artificial
CSF, their pressures dropped to near their opening pressure within 24 minutes.
These data suggest that the decreased CSF pressure in rats given vitamin A is
associated with an increased bulk absorption of CSF, probably due to
pathological membrane or connective tissue changes. J. Nutr. 104: 478-482,
1974.
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